2
Acetil-CoA

Acetoacetil-CoA

NADH + H+

NADH + H+

a-Cetoadipato

NADH/NADPH + H+

NAD+/NADP+ + NH₃⁺

a-Aminoadipato

2-Aminomuconato

NADH/NADPH + H+

NAD+/NADP+

a-Aminoadipato-6-semialdeído

NADH + H+

2-Amino-muconato-6-semialdeido

NAD⁺ + H₂O

NADH + H+, Glutamato, H₂O

Sacaropina

2-Amino-3-carboximuconato- 6-semialdeído

NADH/NADPH + H+, a-cetoglutarato

NADP+/NAD+, H₂O

Lisina

NADPH + H+

Visão geral do processo

Triptofano + 3O₂ + 3H₂O + 2NAD(P)H + 3NAD⁺ + FAD + CoA-SH ---> Acetil-CoA + NAD(P)⁺ + NADH + FADH₂ + 4CO₂
Lisina +2a-Cetoglutarato +2NAD⁺ + NAD(P)⁺ + FAD + 2H₂O ---> Acetil-CoA +Glutamato +2NADH +NAD(P)H + FADH₂ + 2CO₂

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